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KMID : 0357520170400010093
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Journal of Radiological Science and Technology
2017 Volume.40 No. 1 p.93 ~ p.99
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A Monte Carlo Study of Dose Enhancement according to the Enhancement Agents
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Kim Jung-Hoon
Kim Chang-Soo
Hwang Chul-Hyan
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Abstract
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Dose enhancement effects at megavoltage (MV) X and γ-ray energies, and the effects of different energy levels on incident energy, dose enhancement agents, and concentrations were analyzed using Monte Carlo simulations. Gold, gadolinium, Iodine, and iron oxide (Fe2O3) were compared as dose enhancement agents. For incident energy, 4, 6, 10 and 15 MV X-ray spectra produced by a linear accelerator and a Co-60 γ-ray were used. The dose enhancement factor (DEF) was calculated using an ICRU Slab phantom for concentrations of 7, 18, and 30 mg/g. The DEF was higher at higher concentrations of dose enhancement agents and at lower incident energies. The calculated DEF ranged from 1.035 to 1.079, and dose enhancement effects were highest for iron oxide, followed by iodine, gadolinium, and gold. Thus, this study contributes to improving the therapeutic ratio by delivering larger doses of radiation to tumor volume, and provides data to support further in vivo and in vitro studies.
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KEYWORD
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Monte Carlo simulation , Dose enhancement agent , Dose enhancement factor
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